MALE CONTRACEPTIVE PILL HAS BEEN CREATED BUT IT HAS TO BE TAKEN RIGHT BEFORE SEX

 MALE CONTRACEPTIVE PILL HAS BEEN CREATED BUT IT HAS TO BE TAKEN RIGHT BEFORE SEX

The ‘on demand’ therapy blocks a fertility protein – for 24 hours. Scientists say that, in some ways, it is more effective than women’s oral birth control medications which have to be taken daily.To get more news about where to buy vigrx plus, you can visit vigrxplus-original.com official website.

In experiments, the non-hormonal compound stopped mouse sperm cells in their tracks – preventing them from maturing. The animals’ sexual functioning was normal. But while male lab rodents mated with females – there were no pregnancies.

Lead author Dr Melanie Balbach said: ‘Our inhibitor works within 30 minutes to an hour. Every other experimental hormonal or non-hormonal male contraceptive takes weeks to bring sperm count down or render them unable to fertilise eggs.’

The drug temporarily disables an enzyme called sAC (soluble adenylyl cyclase) – which triggers the cells to swim. Dr Balbach said: ‘Sperm recovered from female mice remained incapacitated. There were no side effects. The compound wore off three hours later, and males recovered their fertility.’

A single dose rendered sperm immobile for up to two-and-a-half hours – with the effects persisting in the female reproductive tract after sex. There were 52 attempts at impregnation – and all failed. In contrast, peers treated with a placebo that acted as a control made a third of their partners pregnant.
After three hours, some sperm began regaining motility, with virtually all recovering a day later. The team at Weill Cornell Medicine, New York, hailed the breakthrough as a potential ‘game changer’ for birth control.

Scientists have been trying to develop an effective male oral contraceptive for decades. Targeting testosterone has previously led to obesity, depression and high cholesterol. Women’s choices range from pills to patches to intrauterine devices. As a result, they bear most of the burden of preventing pregnancy. Meanwhile, men have just two – condoms or a vasectomy.

The former are single-use only and prone to failure. The latter is surgical sterilisation which is expensive to reverse – and not always successful. It takes weeks to reverse the effects of other hormonal and non-hormonal male contraceptives in development, said Dr Balbach.

But this new treatment wears off within hours and could allow men to make day-to-day decisions about their fertility, she explained.

Co author Professor Lonny Levin said: ‘The team is already working on making sAC inhibitors better suited for use in humans.’ They have already launched Sacyl Pharmaceuticals. The next step is repeating the study in a different pre-clinical model to lay the groundwork for clinical trials.

They would test the effect on sperm motility in healthy human males, said co author Prof Jochen Buck. If successful, Prof Levin added he hopes to walk into a pharmacy one day and hear a man request ‘the male pill.’